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目的 了解麻疹－乙脑二联活疫苗注射小白鼠脑内的安全性及神经组织病理变化。方法 小白鼠 脑内注射二联活疫苗后，观察体征反应和组织病理变化。结果注射后５～９ｄ有个别小鼠发病，１１～１４ｄ恢复正 常。脑组织病理检查时有轻微病变，７ｄ较明显，２１ｄ基本消退；病变以神经细胞变性及炎性细胞浸润为主，病变 分值在Ｖ－１，个别达Ｖ－２级。上述结果与同批单价乙脑活苗相同，而同批单价麻疹活苗和冻干保护剂却无体征反 应，也无组织病理损伤。结论二联苗注射小白鼠脑内后的体征反应和脑组织病理变化系乙脑１４－２株病毒所致。
Objective To understand the safety and histopathological changes in the brain of mice infected with measles-JE vaccine. Methods The mice were injected intraperitoneally with live vaccine and the signs and histopathological changes were observed. Results 5 to 9 days after injection, some mice developed morbidity and returned to normal after 11-14 days. Pathological examination of brain lesions were mild, 7d more obvious, 21d basically dissipated; lesions of nerve cell degeneration and inflammatory cell infiltration, lesions in the V-1, some of the V-2 level. The above results with the same unit price of JE live the same, and the same unit price of measles live vaccine and lyoprotectants without signs of physical reaction, no histopathological damage. Conclusions The signs and brain pathological changes of the mice injected with Biloba vaccine are caused by JE-14-2 virus.