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采用ＡＢＣ和限制性片段长度多态性（ＲＦＬＰ）检测了４８例非霍奇金淋巴瘤（ＮＨＬ）中１７ｐ杂合性丢失（ＬＯＨ）的情况，发现１２例发生ＬＯＨ，阳性率为２５．０％，尤其是在恶性程度较高的弥漫型大细胞性淋巴瘤（ＤＬＣＬ）中阳性率为６２．５％，显著高于非ＤＬＣＬ中的１７．５％（Ｐ＜０．０１），提示１７ｐＬＯＨ与ＮＨＬ的病理类型有一定的相关性；而且，ＬＯＨ与突变型ｐ５３的表达也有相关性，在有突变型ｐ５３蛋白表达的ＮＨＬ中ＬＯＨ为６６．７％，在无突变型ｐ５３蛋白表达的ＮＨＬ中ＬＯＨ为３３．３％（Ｐ＜０．０５）。作者认为，在国人ＮＨＬ中可同时存在ｐ５３突变和１７ｐＬＯＨ，与ＮＨＬ中ＤＬＣＬ的发生和发展有较明显的相关性。
The heterozygosity of 17p heterozygosity loss (LOH) in 48 cases of non-Hodgkin lymphoma (NHL) was detected by ABC and RFLP, and 12 cases of LOH were found, with a positive rate of 25.0. %, especially in high-grade diffuse large cell lymphoma (DLCL), the positive rate was 62.5%, significantly higher than 17.5% in non-DLCL (P<0.01), suggesting 17pLOH There is a certain correlation with the pathological type of NHL; moreover, there is also a correlation between LOH and the expression of mutant p53. In the NHL with mutant p53 protein, the LOH is 66.7%, and in the NHL without mutant p53 protein expression. The median LOH was 33.3% (P<0.05). The authors believe that there may be both p53 and 17pLOH in Chinese NHL, which has a significant correlation with the occurrence and development of DLCL in NHL.