晚期糖基化终末产物(advanced glycosylation end products,AGEs)是糖酮或醛基与蛋白、脂质、氨基酸的自由氨基经不可逆反应所形成的物质,是非酶糖基化反应的最终产物。研究发现在动脉硬化、心肌舒张异常及内皮功能紊乱等心血管疾病中都出现AGEs水平的增加,并且抑制AGEs的产生或作用具有心血管保护作用。因此,AGEs可以作为防治心血管疾病的一个潜在靶点。本文重点综述了AGEs的来源、心血管损伤机制及防治策略。 Advanced glycosylation end products (AGEs) are substances formed by the irreversible reaction of sugar ketones or aldehyde groups with free amino groups of proteins, lipids and amino acids, which are the final products of non-enzymatic glycosylation reactions. The study found that in arteriosclerosis, myocardial dilation and endothelial dysfunction and other cardiovascular diseases have increased in AGEs levels, and inhibition of AGEs production or the role of cardiovascular protection. Therefore, AGEs can be used as a potential target for the prevention and treatment of cardiovascular diseases. This article focuses on the sources of AGEs, cardiovascular damage mechanisms and control strategies.