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目的:探讨帕罗西汀治疗卒中后抑郁患者效果以及对神经康复的影响。方法:将82例脑卒中后抑郁患者随机分为治疗组和对照组,2组均给予常规神经内科药物治疗、心理干预及神经康复治疗,治疗组同时给予帕罗西汀抗抑郁治疗。分别于治疗前、后采用神经功能缺损评分量表(NIHSS)、汉密尔顿抑郁量表(HAMD)对患者抑郁及神经功能缺损程度进行评定。结果:治疗4周后治疗组患者在神经功能缺损、抑郁程度改善方面均优于对照组,差异有显著性意义(P<005)。结论:帕罗西汀治疗卒中后抑郁具有较好的疗效并能促进患者的神经功能康复。
Objective: To investigate the effect of paroxetine on post-stroke depression and its effect on neurological rehabilitation. Methods: Eighty-two patients with post-stroke depression were randomly divided into treatment group and control group. Both groups were given routine neurological medical treatment, psychological intervention and neuro-rehabilitation. The treatment group was treated with paroxetine antidepressant at the same time. Neurological deficit score (NIHSS) and Hamilton Depression Rating Scale (HAMD) were used to evaluate the degree of depression and neurological impairment before and after treatment. Results: After 4 weeks of treatment, the patients in the treatment group were better than the control group in improving neurological deficits and depression, the difference was significant (P <005). Conclusion: Paroxetine has a good effect on post-stroke depression and can promote neurological rehabilitation in patients.