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有报道胰岛素可以导致大鼠肾小球系膜中纤维连接蛋白 (Ｆｎ)堆积[1] ,提示高胰岛素血症可能在糖尿病肾病 (ＤＮ)发生发展中有其作用。本研究拟建立人类肾小球系膜细胞 (ＧＭＣ)培养 ,观察高胰岛素对人类ＧＭＣ增生及Ｆｎ生成 ,ＧＭＣ内游离Ｃａ2 +([Ｃａ2 + ]ｉ)水平的影响 ,以
It has been reported that insulin can lead to the accumulation of fibronectin (Fn) in rat mesangial cells [1], suggesting that hyperinsulinemia may play a role in the development of diabetic nephropathy (DN). In this study, human mesangial cells (GMC) were cultured to observe the effects of hyperinsulin on the proliferation of human GMCs and the generation of Fn and the level of intracellular free Ca2 + ([Ca2 +] i) in GMCs.