论文部分内容阅读
脊髓灰质炎是一种由脊髓灰质炎病毒引发的高感染性疾病,该病可导致瘫痪甚至致命。口服脊髓灰质炎减毒活疫苗(live attenuated oral poliovirus vaccine,OPV)和脊髓灰质炎灭活疫苗(inactivated poliomyelitis vaccine,IPV)的使用为全球消灭脊髓灰质炎的主要途径,但目前的OPV及IPV均存在生物安全隐患。脊髓灰质炎病毒类病毒颗粒(virus-like particles,VLPs)可保留原病毒的大量重要抗原表位,诱导较强的免疫反应,且无生物安全隐患,是一种具有巨大潜力的疫苗。本文结合全球范围内OPV与IPV的使用情况,对目前脊髓灰质炎病毒VLPs的研究现状及其作为脊髓灰质炎疫苗的意义和目前的困难作一综述。
Polio is a highly infectious disease caused by poliovirus that can cause paralysis and even fatal. The use of live attenuated oral poliovirus vaccine (OPV) and inactivated poliomyelitis vaccine (IPV) is the main route to eradicate polio in the world, but both OPV and IPV There are biosafety risks. Poliovirus-like particles (VLPs), which retain a large number of important antigenic epitopes of the provirus and induce strong immune responses without potential biosafety, are potentially of great potential. In this paper, combined with the use of OPVs and IPVs worldwide, the current status of research on poliovirus VLPs and their significance as polio vaccines and their current difficulties are reviewed.