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目的:探讨乳腺恶性分叶状肿瘤的临床特点、治疗方法和预后。方法:回顾性分析2例妊娠合并乳腺巨大恶性分叶状肿瘤的诊治过程,并复习相关文献。结果:第1例患者经手术切除后局部复发,再次手术切除、局部放疗后随访至今,未见肿瘤复发转移;第2例患者,手术后短期内局部复发,再次手术后迅速出现双肺、胸膜转移,化疗疗效不显著,患者最终死亡。结论:乳腺恶性分叶状肿瘤的异质性显著,其诊治方法仍需要不断探索。
Objective: To investigate the clinical features, treatment and prognosis of breast malignant lobulated tumors. Methods: Two cases of diagnosis and treatment of giant malignant lobular tumor in pregnancy were retrospectively reviewed, and the related literatures were reviewed. Results: The first patient underwent local resection after surgical resection, resection was performed again. After the local radiotherapy follow-up till now, no tumor recurrence and metastasis was found. In the second patient, the local recurrence occurred shortly after surgery and lungs and pleura appeared rapidly Metastasis, chemotherapy efficacy is not significant, the patient eventually died. Conclusion: The heterogeneity of breast malignant lobulated tumor is significant. The diagnosis and treatment methods still need to be explored.