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我们过去的研究工作表明Graves病(GD)患者具有外周血T细胞亚群的异常,即辅助性T细胞(T_H)增多;抑制性T细胞(Ts)减少;T_H/T_s比值升高。同时,通过观察他巴唑对自身混合淋巴细胞反应的影响,我们也证明了他巴唑具有免疫调节作用。本文在此基础上,进一步观察了经他巴唑治疗不同时间后GD患者T细胞亚群的变化,以深入探讨本病患者的T细胞亚群与临床治疗的关系。
Our previous work showed that patients with Graves’ disease (GD) had abnormal T cell subsets in peripheral blood, ie, increased number of helper T cells (T_H), decreased number of inhibitory T cells (Ts), and increased T_H / T_s ratio. At the same time, we also demonstrated that methimazole has an immunomodulatory effect by observing the effect of methimazole on its own mixed lymphocyte reaction. Based on this, we further observed the changes of T lymphocyte subsets in patients with GD after different periods of treatment with metoprolol to further explore the relationship between T cell subsets and clinical treatment in patients with this disease.