Background: Following a series of reports on central nervous system (CNS) related side effects of topical brimonidine tartrate 0.2% in pediatric patients, this drug can be considered a good representative of topical ocular therapeutics that has the potential to cause significant CNS side effects. Purpose: To examine the neuro-ocular tissue distribution of topical brimonidine. Background: Following a series of reports on central nervous system (CNS) related side effects of topical brimonidine tartrate 0.2% in pediatric patients, this drug can be considered a good representative of topical ocular therapeutics that has the potential to cause significant CNS side effects. Purpose: To examine the neuro-ocular tissue distribution of topical brimonidine.