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目的研究非类固醇抗炎药物苏灵大对Ｎ甲基Ｎ亚硝基脲（ＭＮＵ）诱导小鼠大肠肿瘤的抑制作用，探讨苏灵大对大肠肿瘤的化学性预防作用及其作用机理．方法采用ＭＮＵ直肠内灌注诱导小鼠大肠癌模型．在第１实验中自第１周起诱癌组和对照组同时给予直肠内灌注ＭＮＵ（４ｇ／Ｌ，０４ｍｌ３次／周×６周，１次／周×６周）１２周和口服苏灵大液体（７５ｍｇ／Ｌ）１８周；在第２实验中，小鼠先给予ＭＮＵ直肠内灌注１２周，而后随机分为苏灵大组和对照组，苏灵大组小鼠给予口服含苏灵大液体１８周．在各实验结束时处死各组小鼠，观察和计数结肠内肿瘤数量，测量平均肿瘤直径和平均肿瘤体积，观察诱导肿瘤的组织形态学特征．结果诱导的肿瘤均位于大肠的远端，形态可分为粟粒型、溃疡型和粘膜增厚型．苏灵大组和对照组在诱导的小鼠大肠肿瘤部位分布和肿瘤大体形态方面没有显著性差异．在诱导出现肿瘤的结肠全层席卷组织切片上，第１实验中苏灵大组平均腺瘤数量（８４）明显高于对照组（４７），腺癌平均数量（３９）低于对照组（９３）；而在第２实验中两组间没有明显的差异性．第１实验中，苏灵大组诱导出现肿瘤的小鼠数量（苏灵大组３７５％，对照组７９２％）、肿瘤灶数量（苏灵大组?
Objective To investigate the inhibitory effect of non-steroidal anti-inflammatory drug Su Lingda on N-methylNnitrosourea (MNU)-induced colorectal tumors in mice and to explore the protective effect of Su Lingda on colorectal tumors and its mechanism of action . Methods The model of colorectal cancer in mice was induced by intrarectal injection of MNU. In the first experiment, from the 1st week, the cancer-inducing group and the control group were given intrarectal MNU (4g/L, 04ml 3 times/week×6 weeks, 1 time/week×6 weeks) and 12 weeks. Lingda liquid (75mg/L) for 18 weeks; In the second experiment, MNU mice were given intrarectal perfusion for 12 weeks, and then randomly divided into Sulingda group and control group. Sulingda group mice were given orally. With Su Ling large liquid for 18 weeks. At the end of each experiment, each group of mice was sacrificed, and the number of colonic tumors was observed and counted. Mean tumor diameters and mean tumor volumes were measured to observe the histomorphological characteristics of the induced tumors. Results The induced tumors were located in the distal part of the large intestine. The morphology can be divided into miliary type, ulcer type and mucosal thickening type. There was no significant difference in the distribution of the tumor sites and the gross morphology of the tumor between the Sulingda group and the control group. The average number of adenomas (8.4%) in the Sulingda group in the first experiment was significantly higher than that in the control group (4..7). The average number of adenocarcinomas (3.sup.9) Lower than the control group (9. 3); in the second experiment, there was no significant difference between the two groups. In the first experiment, the number of mice that developed tumors in the Sulingda group (37.5% in the Sulingda group and 79.4% in the control group) and the number of tumor foci (Su Lingda group)?