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目的探讨肝细胞癌染色体异常及其临床意义。方法运用比较基因组杂交技术检测25例肝细胞癌染色体DNA异常情况,并与临床指标作相关分析。结果 25例肝癌均存在不同程度的染色体DNA拷贝数的扩增或缺失,较为常见的染色体DNA异常是+1q(72%)、+1p(64%)、+2q(48%)、+2p(48%)、+5q(48%)、+Xq(48%)、+7q(44%)、-4q(48%)、-16p(48%)、-8p(40%)、-17p(36%);相关分析显示+17p、+18p、-8p、-13q、-11q、-8q染色体异常事件与临床指标部分相关。结论肝细胞癌存在明显的染色体异常,部分染色体异常事件是非随机性的,可能与肝癌的发生、发展有关,并与肿瘤的生物学行为和预后相关。
Objective To investigate the chromosomal abnormalities of hepatocellular carcinoma and its clinical significance. Methods Genomic hybridization was used to detect chromosomal DNA abnormalities in 25 cases of hepatocellular carcinoma and its correlation with clinical parameters was analyzed. Results The amplification and deletion of chromosomal DNA copies were found in 25 cases of hepatocellular carcinoma. The more common chromosomal DNA abnormalities were + 1q (72%), + 1p (64%), 2q (48%) and 2p 48%, +5 q (48%), + Xq (48%), +7 q (44%), -4 q %). Correlation analysis showed that the abnormalities of + 17p, + 18p, -8p, -13q, -11q and -8q were correlated with clinical indexes. Conclusion There are obvious chromosomal abnormalities in hepatocellular carcinoma. Some chromosomal abnormalities are nonrandomized, which may be related to the occurrence and development of hepatocellular carcinoma and are related to the biological behavior and prognosis of hepatocellular carcinoma.