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目的:研究藻黄合剂对体外培养人肾小球系膜细胞(GMC)在高糖下分泌MMP-9、TIMP-1的影响。方法:体外培养人肾小球系膜细胞并在高糖培养基中孵育,用含有不同浓度的藻黄合剂培养液进行干预,分别观察24、48h系膜细胞MMP-9和TIMP-1的分泌。结果:藻黄合剂各剂量组在24、48h均显著升高髙糖下MMP-9的分泌(P<0.01);同时降低TIMP-1在48h的分泌(P<0.05,P<0.01)。结论:藻黄合剂可以升高高糖下系膜细胞MMP-9分泌,降低TIMP-1的分泌,这可能是藻黄合剂降解细胞外基质、防治糖尿病肾病的作用机制之一。
OBJECTIVE: To study the effects of algal mixture on the secretion of MMP-9 and TIMP-1 under high glucose in cultured human mesangial cells (GMCs) in vitro. Methods: Human glomerular mesangial cells were cultured in vitro and incubated in high glucose medium. The culture medium containing different concentrations of algae mixture was used to observe the secretion of MMP-9 and TIMP-1 . Results: All doses of aloe-Huang mixture significantly increased the secretion of MMP-9 (P <0.01) at 24 h and 48 h, and decreased the secretion of TIMP-1 at 48 h (P <0.05, P <0.01). CONCLUSION: Alginate can increase the secretion of MMP-9 and decrease the secretion of TIMP-1 in mesangial cells with high glucose, which may be one of the mechanisms of Algae Mixture in degrading extracellular matrix and preventing and treating diabetic nephropathy.