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Verner-Morrison综合征(胰性霍乱)以水样腹泻、低血钾和低氯为特征.它与胰岛内分泌肿瘤及神经节细胞瘤有关.大多数病人血浆中血管活性肠肽(VIP)升高.作者报道了两例复发的难治性胰性霍乱病人,经人白细胞干扰素治疗后,临床症状迅速改善,同时血浆中VIP和其它肽类亦随之下降.病例1,男性,46岁,有多发性内分泌腺瘤特征(MEN-1).1973年发生严重的水样腹泻和低钾血症,并发现胰腺肿瘤.以后反复发作,并出现肝转移性肿瘤.血浆VIP、促胃液素和胰肽(PP)均增高.用链脲霉素、生长激素释放抑制因子、消炎痛、甲基强的松酶和锂剂等治疗均无效用.用人白细胞干扰素(3～6×10~6IU/日肌肉注射)治疗后3天,大便量减少50%.1周后,血浆VIP下降,血清电解质及促胃液素均正常,血清PP仍较高.随访15个月后,血浆VIP及血清PP均正常,肝转移瘤缩小50%以上.
Verner-Morrison syndrome (pancreatic cholera) is characterized by watery diarrhea, hypokalemia, and hypochloria and is associated with pancreatic endocrine tumors and ganglioneuromas, and the plasma vasoactive intestinal peptide (VIP) is elevated in most patients The authors report that two patients with refractory pancreatic recurrent cholera recurred rapidly after treatment with leukocyte interferon (IFN), and the plasma VIP and other peptides also decreased.Patients 1, male, 46 years old, There are multiple features of endocrine adenoma (MEN-1). Severe watery diarrhea and hypokalemia occurred in 1973 and pancreatic tumors were found. Later recurrent and metastatic liver tumors were observed. Plasma VIP, gastrin and Pancreatic peptide (PP) were increased with streptozotocin, somatostatin, indomethacin, methylprednisolone and lithium treatment were ineffective with human leukocyte interferon (3 ~ 6 × 10 ~ 6IU / Day intramuscular injection) 3 days after treatment, the amount of stool reduced by 50% .After 1 week, decreased plasma VIP, serum electrolytes and gastrin are normal, serum PP is still high.After 15 months of follow-up, plasma VIP and serum PP All were normal, liver metastases shrink more than 50%.