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神经元的发育和存活是一项神经科学研究的热门领域,故神经营养、神经保护因子成为目前的研究热点。但迄今为止,人们对有效的神经营养、神经保护因子及其作用机制了解甚少。血管内皮生长因子-B(vascular endothelial growth fac-tor-B,VEGF-B)是VEGF家族的成员,是1996年发现的该家族第3个因子。大多数关于VEGF-B的研究都是致力于其在血管生长方面的作用,而近年来,一些学者把目光聚焦到VEGF-B的促神经发生、神经营养和神经保护的作用,及其通过直接或间接作用于神经元细胞或神经胶质细胞,从而促进其生长及存活。VEGF-B的这种功能使其和多种神经退行性疾病相关,如帕金森病、肌萎缩侧索硬化症、感觉神经末梢的退行性变性疾病等。细胞体外实验和动物模型研究结果提示,转染VEGF-B基因能够改善肌萎缩侧索硬化症、帕金森病、感觉神经末梢的退行性变性疾病的病情进展。
Neuronal development and survival is a hot area of neuroscience research, neurotrophic and neuroprotective factors have become the current research focus. But to date, little is known about the effective neurotrophic, neuroprotective factors and their mechanisms of action. Vascular endothelial growth factor-B (VEGF-B), a member of the VEGF family, was the third factor in this family discovered in 1996. Most studies on VEGF-B are committed to their role in vascular growth. In recent years, however, some scholars have focused their attention on the role of neurogenesis, neurotrophic and neuroprotection of VEGF-B and their direct, Or act indirectly on neuronal cells or glial cells, thereby promoting its growth and survival. This function of VEGF-B makes it related to a variety of neurodegenerative diseases such as Parkinson’s disease, amyotrophic lateral sclerosis, degenerative diseases of sensory nerve endings and the like. The results of in vitro experiments and animal models suggest that transfection of VEGF-B gene can improve the progression of degenerative diseases such as amyotrophic lateral sclerosis, Parkinson’s disease and sensory nerve endings.