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目的研究热休克蛋白60基因单核苷酸多态性rs788016和rs2340690基因型在病例组和对照组中的分布及其与冠心病风险的关系。方法应用Taqman基因分型方法分别检测674例冠心病病人和774名对照的rs788016和rs2340690基因型分布。结果rs788016和rs2340690各基因型在病例组和对照组的分布差异无统计学意义。按性别、年龄、吸烟状况进行分层后,在年龄<60岁的男性现在吸烟层中,病例组中Hsp60基因rs788016GG基因型和rs2340690CC+CT基因型的频率低于对照组;rs788016AA+AG[相当于GG,OR(95%CI)=1.78(1.04～3.03)]为该人群中冠心病发病的危险因素;rs2340690CC+CT[相对于TT,OR(95%CI)=0.58(0.62～5.20)]。分层分析表明,该基因型和冠心病发病无关。采用Logistic回归模型分析男性吸烟组中rs788016基因型与冠心病的关系,调整其他因素后OR(95%CI)=1.74(1.08～2.82)。结论在年龄<60岁男性现在吸烟人群中,rs788016AA+AG基因型可以是冠心病发病的危险因素。
Objective To study the distribution of rs788016 and rs2340690 genotypes of heat shock protein 60 gene in case group and control group and its relationship with risk of coronary heart disease. Methods The genotypes of rs788016 and rs2340690 in 674 CHD patients and 774 controls were detected by Taqman genotyping. Results There was no significant difference in the distribution of rs788016 and rs2340690 among the cases and controls. In stratified by sex, age and smoking status, the frequencies of rs788016GG genotype and rs2340690CC + CT genotypes in Hsp60 genotypes and rs2380690CC genotypes in the case group were lower than those in the control group. (95% CI = 1.78 (1.04-3.03)] was a risk factor for coronary heart disease in this population; rs2340690CC + CT [95% CI 0.58 (0.62-5.20) vs. TT) . Hierarchical analysis showed that the genotype and coronary heart disease has nothing to do. Logistic regression model was used to analyze the association between rs788016 genotypes and coronary heart disease in male smoking group. OR (95% CI) = 1.74 (1.08-2.82) after adjustment for other factors. Conclusions rs788016AA + AG genotypes may be risk factors for coronary heart disease in current smoking population of men <60 years of age.