急性病毒性肝炎患者中非甲非乙型肝炎(NANBH)占高比例的事实引起人们极大的重视。许多国家的学者从病原学、流行病学、临床和实验手段等方面对其进行了大量研究。本文扼要介绍有关这方面的研究近况。 一、诊断 鉴于NANBH尚缺乏特殊的临床表现和特异性的病毒学或血清学检查方法,对于该病的诊断主要是采用排除法,即用最敏感的血清学方法证实为急性期血清中HBsAg或抗-HBc和抗-HAV的IgM阴性,同时也排除了其它已知可能引起急性肝功能损害的病毒(EB病毒、巨细胞病毒、δ肝病毒等)、细菌,螺旋体、立克次氏体等非病毒微生物感染以及充血性心功能衰竭、休克或脓毒症、胆道疾病、代谢性肝病(进行性肝豆状核变性和化学 The fact that a high proportion of non-A, non-B hepatitis (NANBH) accounts for acute viral hepatitis has drawn great attention. Scholars in many countries have done a lot of research on etiology, epidemiology, clinical and experimental methods. This article briefly introduces the current research in this area. First, the diagnosis Given NANBH lack of special clinical manifestations and specific virological or serological test methods, the diagnosis of the disease is mainly the use of exclusion method, that is the most sensitive serological confirmed as acute serum HBsAg or Anti-HBc and anti-HAV IgM negative, but also exclude other known viruses that may cause acute liver damage (Epstein-Barr virus, cytomegalovirus, hepatitis delta virus, etc.), bacteria, spirochetes, rickettsia Non-viral microbial infection and congestive heart failure, shock or sepsis, biliary disease, metabolic liver disease (progressive hepatolenticular degeneration and chemistry