巨噬细胞是参与固有免疫和适应性免疫的重要细胞,在抵抗病原体、促进组织发育、维持稳态和修复损伤中有着重要作用。近来研究发现,某些代谢产物可调节表观遗传酶的活性,从而通过表观遗传机制调控巨噬细胞的极化,影响相关疾病的发生发展。为此本文就代谢产物通过表观遗传机制调控巨噬细胞极化的相关研究进展作一综述。 Macrophages are important cells involved in innate immunity and adaptive immunity and play an important role in fighting pathogens, promoting tissue development, maintaining homeostasis and repairing damage. Recent studies have found that some metabolites can regulate the activity of epigenetic enzymes, thereby regulating macrophage polarization through epigenetic mechanisms, affecting the development of related diseases. In this paper, we reviewed the progress of the research on the regulation of macrophage polarization by metabolites via epigenetic mechanisms.