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目的探讨ＡＰＯＥ多态性与血管性痴呆（ＶＤ）和脑梗塞（ＣＩ）的关系。方法应用ＰＣＲ－ＲＦＬＰ技术分析２０例ＶＤ、２４例ＣＩ及２４例健康老年人的ＡＰＯＥ基因型。结果ＶＤ和ＣＩ患者ε３频率均降低（Ｐ＜０．０５），ε４频率均升高（Ｐ＜０．０５），而两组患者间各等位基因频率差异均无统计学意义（Ｐ＞０．０５）；且ε４与血清ＡＰＯＥ、ＡＰＯＢ、ＴＣ、ＬＤＬ－Ｃ正相关，与ＡＰＯＡ、ＨＤＬ－Ｃ负相关。结论ＡＰＯＥ多态性与ＶＤ和ＣＩ的发病机制有关，其在这两种疾病中的作用可能相似。
Objective To investigate the relationship between APOE polymorphism and vascular dementia (VD) and cerebral infarction (CI). Methods APOE genotypes of 20 patients with VD, 24 patients with CI and 24 healthy controls were analyzed by PCR-RFLP. Results The frequency of ε3 was decreased (P <0.05) and the frequency of ε4 was increased in patients with VD and CI (P <0.05). There was no significant difference in the frequencies of alleles between the two groups (P> 0.05) .05). And ε4 was positively correlated with APOE, APOB, TC and LDL-C, but negatively correlated with APOA and HDL-C. Conclusions APOE polymorphism is associated with the pathogenesis of VD and CI, and its role in these two diseases may be similar.