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目的:观察天麻钩藤饮合用坎地沙坦是否能加速逆转高血压病患者颈动脉内膜-中膜厚度的重塑。方法:选取60例经过常规检查符合入选标准的原发性高血压患者,分别单用坎地沙坦(30例)和联合应用天麻钩藤饮(30例)治疗6个月,另选30名正常人为对照组;于试验前,试验结束后予以超声诊断仪测量颈总动脉内膜-中层厚度(IMT)、动脉内径(LD)和IMT/LD。结果:高血压患者颈总动脉IMT、LD较正常对照组明显增加,其IMT/LD较正常对照组也增加;坎地沙坦组和联合用药组血压明显降低。坎地沙坦组的IMT降低但未致正常,其IMT/LD降低亦不明显,而联合用药组的IMT、IMT/LD较坎地沙坦组降低明显,其各项指标均接近正常对照组。结论:天麻钩藤饮合用坎地沙坦较单用坎地沙坦能更有效地逆转高血压患者颈动脉的血管重塑。
Objective: To observe whether Tianma Gouteng Decoction combined with candesartan can accelerate the remodeling of intima-media thickness of carotid artery in hypertensive patients. Methods: Sixty patients with essential hypertension were enrolled in this study. They were treated with candesartan alone (30 cases) and Tianma Gouteng Decoction (30 cases) alone for 6 months, while another 30 The control group was normal. Before the test, the carotid artery intima - media thickness (IMT), arterial diameter (LD) and IMT / LD were measured by ultrasonic diagnostic apparatus. Results: The IMT and LD of common carotid arteries of hypertensive patients increased significantly compared with that of normal control group, and the IMT / LD of normal carotid artery increased as compared with that of normal control group. The blood pressure of candesartan group and combination group decreased obviously. The IMT of candesartan group was lower than that of candesartan group, but the IMT of candesartan group was lower than that of candesartan group. However, IMT and LDL of candesartan group were lower than those of candesartan group . Conclusion: Tianma Gouteng drink combined with candesartan can more effectively reverse the remodeling of carotid artery in patients with hypertension than candesartan alone.