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The Fourth Epididymis (Epid Ⅳ) Workshop was held between December 4th and 7th 2006 in Chatel-Guyon,France. This was the first European venue for these workshops following Epid Ⅲ held in Charlottesville, Virginia,USA in 2002, Epid Ⅱ held in Newcastle, Australia in 1998 and a one-day meeting (later named Epid Ⅰ) in Hong Kong,China in 1992.