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人免疫缺陷病毒Ⅰ型(HIV-1)是艾滋病的主要病原体,HIV-1 Env蛋白在病毒的感染、侵入和干扰机体免疫机能等方面发挥着重要作用,它可以干扰细胞正常的信号转导途径、导致合胞体的形成、引发细胞病变。HIV-1感染的细胞类型包括 CD_4~+辅助T细胞、单核巨噬细胞、树突状细胞、朗罕氏细胞、胎盘滋养层细胞、神经元细胞等。HIV-1感染引发的病理变化与免疫系统的变化密切相关,免疫系统的
Human immunodeficiency virus type 1 (HIV-1) is the major causative agent of AIDS. HIV-1 Env protein plays an important role in virus infection, invasion and disruption of immune function. It can interfere with the normal signal transduction pathway , Leading to the formation of syncytia, causing cytopathic effect. The cell types of HIV-1 infection include CD 4 + helper T cells, mononuclear macrophages, dendritic cells, Langerhans cells, placental trophoblast cells, neuronal cells and the like. The pathological changes caused by HIV-1 infection are closely related to the changes of the immune system, the immune system