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目的:探讨补充核糖对大强度耐力训练大鼠血清自由基和抗氧化指标的影响。方法:24只SD大鼠随机分为安静组、运动组和运动+核糖组,运动组和运动+核糖组进行3周大强度耐力训练,在最后一周训练结束后进行一次力竭性运动,运动后即刻取血并测试各项指标。结果:运动+核糖组大鼠血清还原型辅酶Ⅱ(NADPH)含量、还原型辅酶Ⅱ/氧化型辅酶Ⅱ([NADPH]/[NADP+])比值和6-磷酸葡萄糖脱氢酶(G-6-PD)活性显著高于运动组;运动+核糖组大鼠血清谷胱甘肽还原酶(GR)、谷胱甘肽过氧化物酶(GSH-Px)、过氧化氢酶(CAT)、超氧化物歧化酶(SOD)活性和还原型谷胱甘肽(GSH)的含量显著高于运动组(P<0.05);运动+核糖组大鼠血清MDA含量显著低于运动组(P<0.01)。结论:补充核糖可以提高大强度耐力运动中血清NADPH含量和G-6-PD活性,增强抗氧化酶的活性,有利于运动状态下机体内自由基的消除。
Objective: To investigate the effects of ribose supplementation on serum free radicals and antioxidation in intensive endurance training rats. Methods: Twenty-four Sprague-Dawley rats were randomly divided into three groups: sedentary group, exercise group, exercise + ribose group, exercise group and exercise + ribose group. Three weeks of intensive endurance training was performed. Exhaustive exercise and exercise Immediately after taking blood and test the indicators. Results: The levels of NADPH, the ratio of reduced coenzyme Ⅱ / oxidized coenzyme Ⅱ ([NADPH] / [NADP +]) and the ratio of G-6- PD) were significantly higher than those in the exercise group. The levels of glutathione reductase (GR), glutathione peroxidase (GSH-Px), catalase (CAT), superoxide The activities of SOD and GSH were significantly higher than those of the exercise group (P <0.05). The content of serum MDA of the exercise + ribose group was significantly lower than that of the exercise group (P <0.01). CONCLUSION: Ribose supplementation can increase serum NADPH level and G-6-PD activity in intensive endurance exercise and enhance the activity of antioxidant enzymes, which is beneficial to the elimination of free radicals in the body during exercise.