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口腔扁平苔藓(OLP)是一种发生于口腔黏膜的慢性炎症性疾病,是最常见的口腔黏膜疾病之一。因其长期糜烂病损有恶变现象,WHO将其列入癌前状态。OLP的主要病理改变是基底细胞液化变性及上皮下淋巴细胞浸润,其发病机制尚未完全明确,大量研究证实,OLP是一种由T细胞介导的自身免疫性疾病。近年来,国内外各项相关研究显示,无论在OLP患者的外周血还是口腔局部病损均显示出不同于正常人的T淋巴细胞分布。本文就T淋巴细胞在OLP发病中的作用及其亚群分布变化研究作一综述。
Oral lichen planus (OLP) is a chronic inflammatory disease that occurs in the oral mucosa and is one of the most common oral mucosal diseases. Because of its long-term erosion lesions malignant phenomenon, WHO will be included in the precancerous state. OLP is the main pathological changes of basal cell liquefaction degeneration and subepithelial lymphocyte infiltration, the pathogenesis has not yet completely clear, a large number of studies confirmed that OLP is a T cell mediated autoimmune diseases. In recent years, various related studies at home and abroad have shown that the T lymphocytes in normal OLP patients are different from those in normal persons, both in peripheral blood and oral lesions. In this paper, the role of T lymphocytes in the pathogenesis of OLP and its distribution of subpopulations are reviewed.