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目的研究二甲双胍与多烯磷脂酰胆碱联合应用治疗非酒精性脂肪肝病(NAFLD)的临床效果。方法选取2015年6月至2016年6月收治的96例NAFLD患者,随机分成两组,对照组给予多烯磷脂酰胆碱,治疗组接受二甲双胍与多烯磷脂酰胆碱,观察两组患者治疗总有效率、肝功能和血脂水平的改善情况。结果治疗前,两组患者AST、ALT、TG以及TC等各项指标对比无显著差异(P>0.05);治疗后两组患者AST、ALT、TG以及TC等各项指标明显低于治疗前(P<0.05),且治疗组各项指标的改善情况显著优于对照组(P<0.05)。治疗组治疗总有效率显著高于对照组(P<0.05)。结论二甲双胍与多烯磷脂酰胆碱药物联合治疗NAFLD,可以有效改善肝功能和血脂水平,提升治疗效果,改善患者预后。
Objective To study the clinical effect of combination of metformin and polyene phosphatidylcholine in the treatment of non-alcoholic fatty liver disease (NAFLD). Methods A total of 96 patients with NAFLD admitted from June 2015 to June 2016 were randomly divided into two groups. The control group received polyene phosphatidylcholine, and the treatment group received metformin and polyene phosphatidylcholine. The patients in two groups were treated Total efficiency, improvement of liver function and blood lipid level. Results There was no significant difference in AST, ALT, TG and TC between the two groups before treatment (P> 0.05). After treatment, AST, ALT, TG and TC in the two groups were significantly lower than those before treatment P <0.05), and the treatment group improved significantly all the indicators than the control group (P <0.05). The total effective rate of treatment group was significantly higher than that of control group (P <0.05). Conclusions Metformin and polyene phosphatidylcholine combined with NAFLD can effectively improve liver function and blood lipid level, improve the therapeutic effect and improve the prognosis of patients.