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欧美国家报道有些药物与含有圣约翰草的保健品合用时发生相互作用,可使血药浓度降低,药效减弱,如正在用环孢菌素A治疗的移植患者发生排斥反应等。日本厚生省医药安全局指示在与含有圣约翰草的保健品合用时有相互作用之虞的28种
Europe and the United States reported that some drugs interact with health products containing St. John’s wort, which can reduce the blood concentration and reduce the efficacy. For example, patients who are undergoing cyclosporin A treatment have rejection reactions. Japan Ministry of Health and Welfare Bureau of Health and Safety instructions to contain St John’s wort health products when combined with the risk of interaction of 28 species