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目的:探讨整合蛋白β_1亚基在膀胱移行上皮细胞癌中的表达与癌细胞的病理分级和临床分期的关系。方法:采用免疫组织化学SP法检测30例膀胱移行上皮细胞癌和30例膀胱炎组织石蜡标本整合蛋白β_1亚基表达水平。结果:膀胱移行上皮细胞癌与膀胱炎组织相比.癌组织整蛋白β_1亚基表达减弱或消失(P<0.001)。结论:整合蛋白β_1亚基的表达可能与膀胱移行细胞癌的分化,转移密切相关。
Objective: To investigate the relationship between expression of integrin β 1 subunit in bladder transitional cell carcinoma and pathological grade and clinical stage of cancer cells. Methods: Immunohistochemical SP method was used to detect the expression of integrin β 1 subunit in 30 cases of transitional cell carcinoma of bladder and 30 cases of cystitis. Results: Compared with cystitis, the expression of integrin β_1 subunit in bladder transitional cell carcinoma decreased or disappeared (P <0.001). Conclusion: The expression of integrin β 1 subunit may be closely related to the differentiation and metastasis of bladder transitional cell carcinoma.