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自1959年Evans等首次提出用微核率检测遗传损伤以来,各学者报道了各种环境理化因子诱发微核的研究,但至今尚未见有生物因子——细菌和病毒对哺乳动物微核率影响的研究报道。本实验用本所悉生生物室的无菌豚鼠和无菌兔与在有菌条件下的普通豚鼠和普通兔的骨髓嗜多染红细胞的微核率进行分析比较,发现细菌和病毒对豚鼠和兔的遗传物质的稳定性均有一定的影响。
Since Evans et al. First proposed the use of micronucleus rate to detect genetic damage in 1959, various scholars have reported various studies on micronuclei induced by environmental physicochemical factors. However, no biological factors such as bacteria and viruses have been reported to affect the micronucleus rate in mammals Research reports. In this study, we compared the micronucleus rate of bone marrow polychromatic erythrocytes of common guinea pigs and common rabbits in sterile cells with sterile guinea pigs and sterile rabbits in our laboratory, and found that bacteria and viruses had no effect on guinea pig and The stability of the rabbit’s genetic material has a certain impact.