实验采用免疫组化技术，以５－溴－２－脱氧尿嘧啶（ＢｒｄＵ）为检测指标，对ＤＭＢＡ诱导的金地鼠颊囊癌前病变模型进行动态观察，并与常规病理诊断结果比较。发现动物模型的上皮由正常→癌前病变→癌的连续病变过程中，ＢｒｄＵ阳性细胞标识率呈规律性增高趋势。且其峰值所在分级与常规病理诊断间有大致对应的关系。说明金地鼠颊囊癌前病变具有细胞异常增殖的细胞动力学基础。ＢｒｄＵ可以作为诊断癌变和提示预后的重要参考依据。 The immunohistochemical technique was used to detect the precancerous lesion of the golden hamster cheek pouch induced by DMBA with 5-bromo-2-deoxyuridine (BrdU) as the experimental index and compared with the routine pathological diagnosis. It was found that the positive rate of BrdU-positive cells increased regularly in the epithelium of normal animal from precancerous lesions to cancerous lesions. And the peak of the grading and routine pathological diagnosis have roughly corresponding relationship. This shows that the precocious lesions of the golden hamster cheek pouch have the cell dynamic basis of cell proliferation. BrdU can be used as an important reference for diagnosis of cancer and prognosis.