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目的对抗结核药引起的药物性肝炎进行分析,以提高认识。方法回顾性分析119例抗结核药致药物性肝炎者的发病规律与临床特点。结果影响抗结核药致药物性肝炎的相关因素有患者年龄、用药时间及合并其他疾病等。临床特点肝细胞损伤型56例,胆汁瘀滞型43例,混合型20例。HBsAg阳性组肝损害发生率49.13%,HBsAg阴性组肝损害发生率5.84%。HBV-DNA阳性组肝损害发生率69.69%,HBV-DNA阴性组肝损害发生率6.57%。结论影响抗结核药致药物性肝炎有多种因素,定时检测肝功能,有利于对药物肝炎的防治,特别是合并HBsAg阳性者要调整化疗方案,预防重型肝炎发生。
Objective To analyze the drug-induced hepatitis caused by tuberculosis in order to raise awareness. Methods A retrospective analysis of 119 cases of anti-TB drug-induced hepatitis in the incidence of the law and clinical features. Results The anti-tuberculosis drug-induced hepatitis caused by factors related to patient age, medication time and other diseases combined. Clinical features of hepatocellular injury in 56 cases, 43 cases of bile stasis, mixed 20 cases. The incidence of liver damage was 49.13% in HBsAg positive group and 5.84% in HBsAg negative group. The incidence of liver damage in HBV-DNA positive group was 69.69%, and the incidence of liver damage in HBV-DNA negative group was 6.57%. Conclusion There are many factors influencing drug-induced hepatitis caused by anti-tuberculosis drugs. Regular detection of liver function is conducive to the prevention and treatment of drug-induced hepatitis. In particular, patients with positive HBsAg should adjust the chemotherapy regimen and prevent the occurrence of severe hepatitis.