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以对羟基苯甲酸和乙醇为主要原料,甲磺酸为催化剂,采用在反应体系中加入原甲酸三乙酯加热回流的脱水方法合成尼泊金乙酯,通过高效液相色谱跟踪反应进程,考察诸因素对产物转化率的影响。实验结果显示:原甲酸三乙酯脱水法与传统方法比较能提高目标产物转化率,减少反应时间;合成反应中最佳原料配比为乙醇∶对羟基苯甲酸=3∶1(摩尔比),最佳反应时间为4h。
Using p-hydroxybenzoic acid and ethanol as main raw materials and methanesulfonic acid as catalyst, ethylparaben was synthesized by the dehydration method of adding triethyl orthoformate to the reaction system by refluxing, and the reaction process was followed by high performance liquid chromatography Effect of various factors on product conversion rate. The experimental results show that the dehydration method of triethyl orthoformate can improve the conversion rate of the target product and reduce the reaction time compared with the traditional method. The best ratio of ethanol to p-hydroxybenzoic acid is 3:1 (molar ratio) The best reaction time is 4h.