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为探讨藻藻酯双酯钠(PSS)和甘糖酯(PGMS)对急性心肌梗死(AMI)患者红细胞变形能力(ED)保护作用的机制,检测了52例AMI患者红细胞滤过指数(EFI)、红细胞膜Na~+,K~+ -ATP酶和谷胱甘肽过氧化物酶GSH-Px活性及红细胞膜脂质过氧化物(LPO)的变化,同时观察了PSS和PGMS在体外对ED、Na~+,K~+ -ATP酶、GSH-Px和LPO的影响。结果显示,AMI患者EFI、LPO明显增高,Na~+,K~+ -ATP酶和GSH-Px活性明显降低,与对照组比较差异有极显著性(P<0.001)。AMI患者红细胞与PSS或PGMS在体外温育24h后,EFI、LPO明显降低,Na~+,K~+ -ATP酶和GSH-Px活性明显增高。与温育前比较差异有极显著性(P<0.001),与对照组比较差异无显著性(P>0.05)。提示PSS和PGMS具有保护和提高AMI患者ED的作用,其机制与增强红细胞膜ATP酶和抗氧化酶活性有关。
To investigate the mechanism of protective effects of PSS and PGMS on erythrocyte deformability (ED) in patients with acute myocardial infarction (AMI), the levels of erythrocyte filtration index (EFI) , Erythrocyte membrane Na ~ +, K ~ + -ATPase and glutathione peroxidase GSH-Px activity and the changes of erythrocyte membrane lipid peroxide (LPO). Meanwhile, the effects of PSS and PGMS on ED , Na ~ +, K ~ + -ATPase, GSH-Px and LPO. The results showed that the EFI and LPO of AMI patients were significantly increased, while the activities of Na ~ +, K ~ + -ATPase and GSH-Px were significantly lower than those of the control group (P <0.001). After in vitro incubation of erythrocytes and PSS or PGMS for AMI for 24 hours, EFI and LPO were significantly decreased, and the activities of Na ~ +, K ~ + -ATPase and GSH-Px were significantly increased. Compared with the control before the difference was significant (P <0.001), compared with the control group no significant difference (P> 0.05). These results suggest that PSS and PGMS can protect and improve the ED of AMI patients, and its mechanism is related to the enhancement of ATPase and antioxidant enzyme activities of erythrocyte membrane.