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胆汁酸由胆固醇转化而来,是胆汁的主要成分。其一方面有助于脂肪的消化和吸收,同时也具有一定的细胞毒性。胎儿肝脏在妊娠中期就能够合成胆汁酸,但缺乏代谢能力。如何维持胎儿血清中胆汁酸水平,确保胎儿宫内安全是产科学者关注的问题。近年来,随着对妊娠期肝内胆汁淤积症(ICP)发病机制研究的深入以及肝脏相关转运体研究的成熟,胎盘作为母胎间物质交换重要场所,其是否存在胆汁酸相关转运体引起了学者们的关注。针对胆汁酸在母体和胎儿间的转运及其机制做一综述。
Bile acid is converted from cholesterol, is the main component of bile. On the one hand it helps digestion and absorption of fat, but also has some cytotoxicity. Fetal liver can synthesize bile acid in the second trimester, but lack metabolic capacity. How to maintain the level of bile acid in fetal serum and ensure the safety of the fetus in the fetus is a concern of obstetricians. In recent years, with the deepening of the study on the pathogenesis of intrahepatic cholestasis of pregnancy (ICP) and the maturation of liver-related transporter research, the placenta as an important place for the exchange of matter between maternal and fetal, whether it exists bile acid-related transporter caused scholars Their attention. The bile acid transport between maternal and fetal and its mechanism are reviewed.