论文部分内容阅读
目的:评估血清白蛋白水平在预测食管癌再程放疗预后中的价值。方法:收集病理学确诊的需要接受再程放疗的局部复发食管癌患者,放疗前行血清白蛋白检测,采用Kaplan-Meier法和Log-rank检验进行生存率计算,Cox回归模型分析预后影响因素。结果:血清白蛋白水平与分期有关(P=0.002),差异具有统计学意义(P<0.05);62例患者血清白蛋白高值组(≥35 g/L)的1、3、5年总生存率均高于低值组(<35 g/L)(P=0.001),高值组的6个月和12个月的复发后生存率均高于低值组(P=0.026),以上差异均具有统计学意义(P<0.05);血清白蛋白水平和复发时间是影响总生存时间的独立预后因素(P=0.015和P=0.000),差异具有统计学意义(P<0.05)。结论:食管癌再程放疗前行血清白蛋白检测对预测患者预后具有重要意义。
OBJECTIVE: To assess the value of serum albumin in predicting the prognosis of esophageal cancer re-radiation therapy. Methods: The pathologically confirmed patients with locally recurrent esophageal cancer who underwent reradiation were enrolled. Serum albumin was detected before radiotherapy. The survival rate was calculated by Kaplan-Meier method and Log-rank test. Cox regression model was used to analyze the prognostic factors. Results: Serum albumin level was correlated with staging (P = 0.002), the difference was statistically significant (P <0.05); 62 patients with serum albumin high value group (≥ 35 g / L) (P <0.001). The survival rates at 6 and 12 months in high value group were higher than those in low value group (P = 0.026) (P <0.05). Serum albumin level and recurrence time were independent predictors of overall survival time (P = 0.015 and P = 0.000). The difference was statistically significant (P <0.05). Conclusion: Serum albumin before esophageal cancer reradiation is of great significance in predicting the prognosis of patients.