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目的探讨NGAL、Cys-C与Cr联合检测在双侧输尿管结石继发AKI早期诊断中的临床价值。方法选取2016年3月-2017年3月本院肾内科双侧输尿管结石患者102例,其中继发AKI患者8例,未继发AKI患者94例,分别采用了胶乳增强免疫比浊法、胶乳免疫比浊法及酶比色方法对NGAL、Cys-C与Cr水平进行检测。结果双侧输尿管结石继发AKI组与双侧输尿管结石未继发AKI组相比,肌酐浓度差异有统计学意义(P<0.05),NGAL与Cys-C浓度差异有统计学意义(P<0.01);治疗后的NGAL、Cys-C浓度降低,而Cr浓度与治疗前相比差异无统计学意义(P>0.05)。结论 NGAL是双侧输尿管结石继发AKI疗效观察的更敏感的指标,NGAL、Cys-C与Cr联合检测更具早期诊断价值。
Objective To investigate the clinical value of combined detection of NGAL, Cys-C and Cr in the early diagnosis of AKI secondary to bilateral ureteral calculi. Methods From March 2016 to March 2017, 102 patients with bilateral ureteral calculi in our department of nephrology were enrolled. Among them, 8 patients were secondary AKI and 94 patients were non-secondary AKI. Latex-enhanced immunoturbidimetry, latex Immune turbidimetry and enzyme colorimetric method for the detection of NGAL, Cys-C and Cr levels. Results The creatinine concentrations in secondary AKI group and bilateral ureteral calculi group were significantly higher than those in non-secondary AKI group (P <0.05). There was significant difference between NGAL and Cys-C concentrations (P <0.01) ). After treatment, the concentrations of NGAL and Cys-C decreased, while there was no significant difference between the concentrations of Cr and pre-treatment (P> 0.05). Conclusions NGAL is a more sensitive indicator of secondary AKI in bilateral ureteral calculi. Combined detection of NGAL, Cys-C and Cr may be more useful for early diagnosis.