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目的为探讨样品剂量对Balb/c小鼠体重增长的影响,进行本研究。方法选用28个保健食品,其人体推荐量从0.083~0.225<0.033g/kg体重/d,根据人体推荐剂量设1倍、10倍、30倍3个剂量组,经口灌胃给予小鼠,观察30 d后其体重变化。结果中剂量组对Balb/c小鼠的体重增长有一定的抑制作用,高剂量组对小鼠的体重增长有明显的抑制作用。结论人体推荐量每人在2 g/d以上者采用灌胃方式给予即会对Balb/c小鼠体重产生不良影响。
Objective To investigate the effect of sample dose on body weight gain in Balb / c mice. Methods 28 health foods were selected and their body recommended doses ranged from 0.083-0.225 <0.033g / kg body weight / day. According to the recommended doses of human body, three doses of 1, 10 and 30 times were given to mice. Body weight changes were observed after 30 days. Results The middle dose group had a certain inhibitory effect on the weight gain of Balb / c mice and the high dose group had a significant inhibitory effect on the weight gain of mice. Conclusion Body weight of Balb / c mice is adversely affected by the administration of gavage at a dose of 2 g / d or more.