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对65例急性白血病(AL)进行了形态学、免疫学和细胞遗传学综合分型,其中ALL41例,包括B系ALL21例、T系ALL18例、T/B杂合型2例;ANLL19例中具有粒或单核系免疫表型者11例,8例结合形态学分型与核型分析定为ANLL;另有5例免疫表型及核型等不具有亚型特异性,暂定为急性未定型白血病。检出的特异性染色体异常包括ph、6q~-、12p~-、t(8;21)、t(15;17)、inv(3q)等。形态学检查是AL诊断分型的基本方法,但单纯依靠形态学诊断可能造成分型的偏差;免疫分型有助于ALL的正确诊断与分型,是对ALL形态学诊断的有力补充,而对ANLL的分型目前尚有局限性;核型分析对AL尤其是ANLL的分型诊断有重要意义。
A total of 65 cases of acute leukemia (AL) were classified by morphology, immunology and cytogenetics. Among them ALL41 cases included 21 cases of ALL, 18 cases of T ALL, 2 cases of T / B heterozygous; Eleven patients with granulocyte or mononuclear cell immunophenotype, 8 cases combined with morphological typing and karyotype analysis as ANLL; another 5 cases of immunophenotype and karyotype does not have subtype specificity, tentatively scheduled for acute undetermined Leukemia. Specific chromosomal abnormalities detected include ph, 6q ~ -, 12p ~ -, t (8; 21), t (15; 17), inv (3q) and so on. Morphological examination is the basic method for the diagnosis of AL. However, morphological diagnosis may result in the deviation of typing. Immunophenotyping is helpful for the correct diagnosis and classification of ALL, which is a powerful supplement to the diagnosis of ALL. The classification of ANLL is still limited; karyotype analysis of AL, especially the classification of ANLL is of great significance.