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1980年中除对蒽环化合物,胺苯吖啶(AMSA)、2,4-二氨基-5-(3′,4′-二氯苯基)-6-甲基嘧啶(DDMP)、氯苯二氯乙烷(o,P-DDD)、干扰素、类维生素A类、卡米诺霉素、L-天冬酰胺酶、1-己基甲酰基-5-氟脲嘧啶、5-氟-1,3-双(四氢-2-呋喃基)脲嘧啶(FD-1)及亚硝脲类进行综述外,已报道的有关文章约有2000篇。本文就值得重视的新抗瘤药物方面加以概述。烷化剂对90种亚硝脲类化合物进行了定量构-效关系研究。其中1-(2-氯乙基)-1-亚硝基-3-
In addition to the anthracene ring compound in 1980, amine acridine (AMSA), 2,4-diamino-5- (3 ’, 4’- dichlorophenyl) -6-methylpyrimidine (DDMP), chlorobenzene Dichloroethane (o, P-DDD), Interferons, Retinoids, Camelomycin, L-Asparaginase, 1-Hexanoyl-5-fluorouracil, , 3-bis (tetrahydro-2-furanyl) uracil (FD-1) and nitrosoureas, there are about 2,000 reported articles. This article gives an overview of new anti-tumor drugs that deserve attention. Alkylating agents were used to study the structure-activity relationship of 90 kinds of nitrosoureas. Among them, 1- (2-chloroethyl) -1-nitroso-3-