Region runs throughout the whole novel, nearly all characters in novel are affected by religion. Religion had great impact on allcorners of American society at that time, including the ways of thinking of the white and the black people. On the one hand, the philanthropism of Christianity advocates that black people should be treated equally and the slavery absolutely should be abolished. On the other hand, the doctrine of pursuing happiness, freedom and wealth lets the slave owners think that it is granted to preserve the slavery. Not only are there religious contradictions between white people but also between black slaves. This paper mainly analyses the religious contradictions of anti-slavery in America in the 19th century.