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封闭因子是一种小分子的多肽,可存在于肿瘤患者的血清中。体外培养时,它可抑制非特异性致有丝分裂因子,如植物血凝素或刀豆素A对淋巴细胞的转化,从而可反映患者免疫力的变化。在35例肿瘤患者的临床过程中观察到,治疗有效的患者不出现封闭因子,而治疗无效者却可出现。而以前缓解过但目前治疗无效者,体外培养证明其淋巴细胞无反应,说明这并非由于血清封闭因子的存在,而是由于免疫细胞的耗竭所致。患
The blocking factor is a small molecule polypeptide that can be present in the serum of cancer patients. When cultured in vitro, it inhibits the conversion of non-specific mitogenic factors, such as lectin or concanavalin A, to lymphocytes, thereby reflecting changes in the patient’s immunity. In the clinical course of 35 patients with cancer, it was observed that patients with effective treatment did not have a blocking factor, but those who failed to respond could appear. For those who had previously been relieved but are currently not responding, in vitro culture demonstrated no response to lymphocytes, suggesting that this was not due to the presence of serum blocking factors but to the depletion of immune cells. Suffer