瑞斯托霉素(简称R)是从灰黄色土壤丝菌属细菌发酵提取出来的一种抗生素,分子量2500-5000左右,确切的结构还不清楚,是一种多肽类物质,含有阿拉伯胶糖、甘露糖、葡萄糖、鼠李糖等,可治疗革兰氏阳性细菌引起的感染。在临床使用中,因引起血小板聚集(PAG)、纤维蛋白原沉积造成血小板减少及低纤维蛋白原血症而停止应用。 1972年,Howard及Firkin首先报道了R可引起正常人、血小板无力症及低纤维蛋白原血症患者 Ristocetin (referred to as R) is an antibiotic extracted from the bacteria of the yellow-yellow soil genus Trichosporon, the molecular weight is about 2500-5000, the exact structure is not clear, is a polypeptide material containing arabic gum , Mannose, glucose, rhamnose, etc., can treat Gram-positive bacteria caused by infection. In clinical use, it is discontinued due to platelet aggregation (PAG), fibrinogen deposition resulting in thrombocytopenia and hypofibrinogenemia. In 1972, Howard and Firkin first reported that R can cause normal, thrombocytosis and hypofibrinogenemia in patients