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目的:检测着丝粒蛋白-H(CENP-H)在舌鳞状细胞癌中的表达水平,并结合临床病理资料探讨其临床意义。方法:采用免疫组织化学SP法检测168例舌鳞状细胞癌组织石蜡切片中CENP-H的表达情况。所有病例均有完整的临床病理资料,应用SPSS13.0软件包对数据进行统计学处理,分析CENP-H表达水平对舌鳞癌的早期诊断和预后评估的价值。结果:168例舌鳞癌标本中,CENP-H的强阳性率为55.95%(94/168);不同临床分期(P=0.005)、T分期(P=0.004)的CENP-H表达有显著性差异,随分期增高而表达升高;多因素Cox回归分析显示,CENP-H的表达水平(P=0.043)、临床分期(P<0.001)分别是舌鳞癌患者的独立预后因素。生存分析显示,高表达CENP-H的患者生存率显著低于低表达CENP-H的患者(P=0.001);早期舌鳞癌组中CENP-H高表达患者预后较差(P=0.000)。结论:CENP-H可能是与舌鳞癌发生、发展相关的标志物。对舌鳞癌患者的预后评估,特别是对早期患者的预后评估具有重要意义。
Objective: To detect the expression of centromere-H (CENP-H) in tongue squamous cell carcinoma and to explore its clinical significance with clinicopathological data. Methods: Immunohistochemical SP method was used to detect the expression of CENP-H in 168 cases of tongue squamous cell carcinoma tissues. All cases had complete clinical and pathological data. SPSS13.0 software package was used to analyze the data. The value of CENP-H expression in early diagnosis and prognosis of tongue squamous cell carcinoma was analyzed. Results: The positive rate of CENP-H in 168 specimens of tongue squamous cell carcinoma was 55.95% (94/168). There were significant differences in CENP-H expression between different clinical stages (P = 0.005) and T stage (P = 0.004) (P = 0.043), clinical stage (P <0.001) were independent prognostic factors in patients with TSCC, respectively. Survival analysis showed that the survival rate of CENP-H-overexpressing patients was significantly lower than that of patients with low expression of CENP-H (P = 0.001). The prognosis of CENP-H overexpression in early tongue squamous cell carcinoma was poor (P = 0.000). Conclusion: CENP-H may be related to the occurrence and development of tongue squamous cell carcinoma. The prognosis of patients with TSCC, especially for the early prognosis of patients is of great significance.