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目的观察不同剂量米非司酮治疗子宫肌瘤的临床效果。方法抽取我院2015年1月至2016年12月收治的82例子宫肌瘤患者作为实验对象,根据双盲法将82例患者分成两组,取其41例患者应用米非司酮治疗用药量为每日25mg设作对照组,另外41例患者应用米非司酮治疗用药量为每日12.5mg设作观察组,经过3个月治疗后,对比两组治疗效果、不良反应等情况。结果观察组有效率97.56%,对照组有效率80.49%,与对照组比较观察组有效率更高;观察组不良反应发生率4.88%,对照组不良反应发生率19.51%,与对照组比较观察组不良反应发生率更低;两组对比有显著差异(P<0.05),具有可比性。结论不同剂量米非司酮治疗子宫肌瘤效果较好,可以降低不良反应发生率,值得推广应用。
Objective To observe the clinical efficacy of different doses of mifepristone in the treatment of uterine fibroids. Methods Totally 82 patients with uterine fibroids admitted from January 2015 to December 2016 in our hospital were enrolled. According to the double-blind method, 82 patients were divided into two groups. 41 patients were treated with mifepristone 25mg daily for the control group, another 41 patients with mifepristone treatment dose of 12.5mg per day for the observation group, after 3 months of treatment, the two groups compared the treatment effect, adverse reactions and so on. Results The effective rate of the observation group was 97.56%, the effective rate of the control group was 80.49%, the observation group was more effective than the control group; the incidence of adverse reactions in the observation group was 4.88%, the incidence of adverse reactions in the control group was 19.51% The incidence of adverse reactions was lower; there was significant difference between the two groups (P <0.05), comparable. Conclusion Different doses of mifepristone treatment of uterine fibroids better, can reduce the incidence of adverse reactions, it is worth promoting the application.