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目的:研究辛伐他汀对治疗并发高脂血症的颈动脉粥样硬化斑块的影响,以及合用格列吡嗪对辛伐他汀的增效作用。方法:将高脂血症并发颈动脉粥样硬化患者108例,随机分为2组,辛伐他汀治疗组和格列吡嗪合并辛伐他汀治疗组,6个月治疗后,测量血脂生化指标、炎症因子活性和高频率彩色多普勒超声内-中膜厚度(IMT)。结果:两个治疗组,治疗后与治疗前相比,血脂指标,炎症因子指标及其IMT值都具有显著性差异(P<0.05)。与辛伐他汀单独治疗相比,格列吡嗪合并辛伐他汀治疗组的TC、TG和HDL-C没有显著性差异(P>0.05),但LDL-C显著减少(P<0.05),两组间ET-1和TNF-α以及IMT值差异显著(P<0.05)。结论:辛伐他汀能够改善血脂水平,降低炎症因子活性,进而对颈动脉粥硬化具有治疗作用,而合并格列吡嗪治疗能够起到增效作用。
OBJECTIVE: To study the effect of simvastatin on carotid atherosclerotic plaque in the treatment of hyperlipidemia and the synergistic effect of simvastatin with glipizide. Methods: One hundred and eight patients with hyperlipidemia complicated with carotid atherosclerosis were randomly divided into 2 groups, simvastatin treatment group and glipizide combined with simvastatin treatment group. After 6 months of treatment, blood lipid biochemical indexes , Inflammatory factor activity and high frequency color Doppler ultrasound intima-media thickness (IMT). Results: Compared with pretreatment, the levels of serum lipid, inflammatory cytokines and IMT in two treatment groups after treatment were significantly different (P <0.05). Compared with simvastatin alone, there were no significant differences in TC, TG and HDL-C between glipizide and simvastatin (P> 0.05), but LDL-C was significantly decreased (P <0.05) There were significant differences in ET-1, TNF-α and IMT between groups (P <0.05). Conclusion: Simvastatin can improve blood lipids, reduce the activity of inflammatory cytokines, and then have a therapeutic effect on carotid atherosclerosis, while the combination of glipizide treatment can play a synergistic effect.