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目的探讨一氧化氮（NO）对分娩时子宫收缩和胎儿-胎盘循环系统的影响及其意义。方法应用荧光分光光度法对明式分娩组25例，剖宫产组49例的母、胎血NO进行比较。结果剖宫产组的母血和脐血的NO值分别明显高于阴式分娩组（P＜0．05）。在剖宫产组中20例无宫缩剖宫产组的母血和脐血的NO值分别明显高于29例有宫缩剖宫产组（P＜0．01和P＜0．05）。在有宫缩剖宫产组中18例第一产程手术组的母血和脐血的NO值分别明显高于11例第二产程手术组（P＜0．01和P＜0．05）。新生儿窒息的脐血NO值明显低于无新生儿窒息者（P＜0．01）。结论NO的合成、释放减少对子宫平滑肌组织及血管产生收缩作用，可引起分娩发动，并对维持分娩发挥作用，但NO过度减少容易产生新生儿窒息。
Objective To investigate the effect and significance of nitric oxide (NO) on uterine contraction and fetal-placental circulatory system during labor. Methods Fluorimetric method was used to compare the mothers ’and fetus’ blood NO in 25 cases in the delivery group and 49 cases in the cesarean section group. Results The cesarean section group of maternal blood and umbilical cord blood NO value was significantly higher than the vaginal delivery group (P <0.05). In the cesarean section group, 20 cases of non-uterine contractions cesarean section group of maternal blood and umbilical blood NO values ?? were significantly higher than 29 cases of uterine contractions cesarean section group (P <0.01 and P <0.05) . The NO values of maternal blood and umbilical blood of 18 patients in the first stage of labor with labor in the uterine contractions cesarean section group were significantly higher than those in 11 cases of the second stage labor group (P <0.01 and P <0.05), respectively. Neonatal asphyxia in cord blood NO was significantly lower than those without neonatal asphyxia (P <0.01). Conclusion NO synthesis and release reduce the contraction of uterine smooth muscle tissue and blood vessels, can cause labor to start, and to maintain the role of labor, but excessive NO prone to neonatal asphyxia.