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选择不同暴露水平的二甲苯接触个体,检测个体二甲苯暴露浓度,同时采集当日工人班末尿样,对尿中二甲苯的代谢产物甲基马尿酸的含量进行测定,将二甲苯的外暴露空气浓度与体内甲基马尿酸代谢量进行回归分析,结合国外限值资料,提出适合我国职业卫生现状的甲基马尿酸生物限值的建议。接触工人在空气中二甲苯浓度为0～144.21 mg/m3时,班末尿中甲基马尿酸(MHA)与空气中二甲苯浓度之间存在良好相关性,肌酐校正回归方程为y(g/g肌酐)=0.0052x(mg/m3)+0.0112,r=0.731;比重校正回归方程为y(g/L)=0.0089x(mg/m3)-0.0259,r=0.793。将我国二甲苯职业接触限值50 mg/m3分别代入回归方程,推出工作班末尿中甲基马尿酸含量为0.271 g/g肌酐和0.419 g/L。依据我国二甲苯实际接触情况,参考国外相关标准和文献,建议我国职业接触二甲苯的代谢产物尿中甲基马尿酸的生物接触限值为班末尿0.3 g/g肌酐或0.4 g/L。
Xylene exposed to different exposure levels was selected to test individual exposure to xylene. At the same time, urine samples from workers at the end of the day were collected to determine the content of methyl hippuric acid, a metabolite of xylene in the urine. The exposed air of xylene Concentration and the amount of hippuric acid metabolism in vivo regression analysis, combined with the limits of foreign data, put forward the status of occupational health methyl hypourine methyl hydrogen limit recommendations. There was a good correlation between methylmaleic acid (MHA) in the paraquat and xylene concentration in the air when exposed to xylene in air at a concentration of 0 ~ 144.21 mg / m3. The equation of creatinine correction was y (g / g creatinine = 0.0052x (mg / m3) + 0.0112, r = 0.731. The regression equation of gravity correction was y (g / L) = 0.0089x (mg / m3) -0.0259, r = 0.793. The occupational exposure limit of xylene in China was substituted into the regression equation respectively, and the content of methyl hippuric acid in working-class urine was 0.271 g / g creatinine and 0.419 g / L respectively. Based on the actual contact situation of xylene in our country and referring to relevant foreign standards and references, we suggest that the limit of bioavailability of methyl hippurate in urinary metabolite of occupational exposure to xylene in our country is 0.3 g / g creatinine or 0.4 g / L.