肝细胞生长因子(HGF)是一种多功能细胞因子,其生物学活性由c-Met蛋白所介导,通过多种途径调节细胞的生长,发挥重要的生理效应。Met活化失调在许多肿瘤的发生及侵袭中都有重要的作用。目前,对HGF/c-Met系统的研究已取得了很大进展。c-Met抑制剂成为抗肿瘤药物的研究热点,其中NK4能显著抑制肿瘤的生长、增殖和转移,本文对NK4在抗肿瘤方面的作用做一综述。 Hepatocyte growth factor (HGF) is a multifunctional cytokine whose biological activity is mediated by c-Met protein and plays an important physiological role in regulating cell growth through a variety of pathways. Met activation disorder plays an important role in the occurrence and invasion of many tumors. At present, great progress has been made in the research of HGF / c-Met system. C-Met inhibitors have become the research hotspot of anti-tumor drugs. Among them, NK4 can significantly inhibit tumor growth, proliferation and metastasis. This article reviews the anti-tumor effect of NK4.