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本研究观察了当机体摄入不同放射量裂变产物~(147)Pm时的体内选择性蓄积部位骨髓细胞染色体畸变、姐妹染色单体互换(SCE)频率和微核率变化的诱发效应。实验结果表明,小剂量~(147)Pm以诱发骨髓细胞染色单体型畸变为主。而随着~(147)Pm摄入量的增加,可出现染色体断裂和易位。~(147)Pm摄入量与骨髓细胞染色体畸变率之间呈半对数直线效应关系,拟合的对数回归方程式为:Y=10.69+1.435InX。同时骨髓畸变细胞与~(147)Pm摄入量之间亦呈现线性关系,拟合的方程式为:Y=9.61+1.24InX,~(147)Pm内污染机体后,可诱发骨髓细胞SCE率和微核的阳性率明显升高,且随着~(147)Pm摄入量的加大,微核阳性率亦进一步增升。
This study investigated the chromosomal aberrations of bone marrow cells, sister chromatid exchange (SCE) frequency, and the evoked effect of changes in micronucleus frequency in selective accumulation sites in the body when ingesting different amounts of fission product ~147Pm. The experimental results showed that low-dose ~(147)Pm induced bone marrow cell chromatid-type aberrations. With the increase of ~(147)Pm intake, chromosome breakage and translocation can occur. The relationship between ~(147)Pm intake and chromosome aberration rate of bone marrow cells was a semi-logarithmic linear effect. The fitted logarithmic regression equation was: Y=10.69+1.435 InX. At the same time, there was a linear relationship between bone marrow aberrant cells and ~(147)Pm intake. The fitted equation was: Y=9.61+1.24 InX, ~(147)Pm polluted the body, it could induce bone marrow cell SCE rate and The positive rate of micronucleus was significantly increased, and with the increase of ~(147)Pm intake, the positive rate of micronucleus was further increased.