利用立体定向手术向脑内注入胶原酶或自体血方法制作的脑出血动物模型与人类脑出血发病情况较为接近 ,且出血量及出血部位的重复性较好 ,故应用较多。立体定位下向脑内植入可充胀的微气囊常用于模拟脑出血的占位效应及手术清除血肿过程的研究。自发性脑出血动物模型具有类似人类高血压动脉硬化的病理生理基础 ,但出血量及出血区域无法控制 ,故应用极少。综合自发性脑出血与人工诱导脑出血模型的优点 ,将有可能制作出较为理想的脑出血动物模型。 The use of stereotactic surgery to the brain into the collagenase or autologous blood produced by the method of intracerebral hemorrhage animal model and the incidence of human cerebral hemorrhage is relatively close, and bleeding and bleeding site repeatability is good, it is more used. Stereotactic implantation of intracranial inflatable microcatheter is commonly used to simulate the mass effect of cerebral hemorrhage and surgical resection of the hematoma process. The animal model of spontaneous intracerebral hemorrhage has the pathophysiology of arteriosclerosis similar to human hypertension, but the amount of bleeding and bleeding can not be controlled, so it is rarely used. Combining the advantages of spontaneous intracerebral hemorrhage and artificial induced intracerebral hemorrhage model, it is possible to make an ideal animal model of intracerebral hemorrhage.