自1968年Gramiak首次报道了超声微泡(ultrasound mi-crobubble,UM)的应用以来,UM的研究开发取得突飞猛进的进展。近年来研究发现,靶向微泡由于能够从分子水平识别并结合于病灶,从而在靶点产生特异性显影,因此能更加显著地提高超声对早期病变的诊断能力。同时,可以将UM作为携带 Since the first application of ultrasound mi-crobubble (UM) by Gramiak in 1968, advances in UM research and development have been made. In recent years, it has been found that targeted microbubbles can specifically identify the target at the molecular level because of its ability to recognize and bind to the lesion at the molecular level, thereby significantly improving the ability of ultrasound to diagnose early lesions. At the same time, UM can be carried as