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作者通过一项以安慰剂对照的双盲随机性前瞻研究,证实了巯甲丙脯酸对控制急性心肌梗塞(AMI)梗塞范围和心律失常的作用。该研究受试者为46例AMI患者(9女,37男;年龄38～86岁,平均61岁),随机分成巯甲丙脯酸治疗组(22例)和安慰剂对照驵(24例),两组在年龄、梗塞部位和接治时间等方面均具可比性。开始本项研究后2～18小时内,治疗组先行静脉缓慢推注巯甲丙脯酸2.5或5mg,随之以1.5～2.0mg/h的速度静脉持续滴注该
The authors tested the effect of captopril on controlling infarct size and arrhythmia in patients with acute myocardial infarction (AMI) through a double-blind randomized prospective study in a placebo-controlled manner. The study participants included 46 AMI patients (9 females, 37 males; age 38-86 years, mean 61 years), who were randomized to receive either captopril (n = 22) or placebo (n = 24) The two groups were comparable in age, infarction location and treatment time. Within 2 to 18 hours after the start of this study, captopril 2.5 or 5 mg was bolted into the treatment group, followed by intravenous infusion at a rate of 1.5-2.0 mg / h